Wednesday, March 19, 2014

Experience of low-dose aminophylline use to relieve minor adverse effects of dipyridamole

BACKGROUND: aminophylline is widely used to reverse dipyridamole-related adverse effects during stress myocardial perfusion imaging (MPI).

METHODS: 2,250 consecutive patients were evaluated.

RESULTS: No severe adverse events were observed. Low-dose (25 mg) aminophylline relieved symptoms in 98.8% of patients with mild adverse events. An additional 25 mg aminophylline reversed the moderate adverse events.

CONCLUSION: aminophylline at 25 mg IV is sufficient to relieve nearly all dipyridamole-related adverse events observed during stress MPI.

J Nucl Cardiol. 2014 Mar 14